　 -Drug Synthesis Database

【结构式】

【分子编号】65812

【品名】　

【CA登记号】　

【分子式】C₉H₁₁NO₂

【分子量】165.19188

【元素组成】C 65.44% H 6.71% N 8.48% O 19.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVI)

The chiral intermediate (XII) is obtained by aminolysis of methyl (S)-(+)-mandelate (XV) with methylamine in MeOH to give 2(S)-hydroxy-N-methylphenylacetamide (XVI), which is treated with p-toluenesulfonyl chloride in the presence of DMAP and DIEA in CH2Cl2 (1). Scheme 3.

参考文献中间体

合成目标

【1】 Weller, T., Koberstein, R., Aissaoui, H., Clozel, M., Fischli, W. (Actelion Pharmaceuticals Ltd.). Substituted 1,2,3,4-tetrahydroisoquinoline derivatives. EP 1751111, JP 2007525531, US 2007191424, WO 2005118548.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XII)	65809	(S)-2-(Methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate	871224-68-9	C₁₆H₁₇NO₄S	详情	详情
(XV)	65811	(S)-(+)-Methyl mandelate; (+)-Methyl (S)-alpha-hydroxyphenylacetate	21210-43-5	C₉H₁₀O₃	详情	详情
(XVI)	65812			C₉H₁₁NO₂	详情	详情

Extended Information