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【结 构 式】

【分子编号】65811

【品名】(S)-(+)-Methyl mandelate; (+)-Methyl (S)-alpha-hydroxyphenylacetate

【CA登记号】21210-43-5

【 分 子 式 】C9H10O3

【 分 子 量 】166.1766

【元素组成】C 65.05% H 6.07% O 28.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XV)

The chiral intermediate (XII) is obtained by aminolysis of methyl (S)-(+)-mandelate (XV) with methylamine in MeOH to give 2(S)-hydroxy-N-methylphenylacetamide (XVI), which is treated with p-toluenesulfonyl chloride in the presence of DMAP and DIEA in CH2Cl2 (1). Scheme 3.

1 Weller, T., Koberstein, R., Aissaoui, H., Clozel, M., Fischli, W. (Actelion Pharmaceuticals Ltd.). Substituted 1,2,3,4-tetrahydroisoquinoline derivatives. EP 1751111, JP 2007525531, US 2007191424, WO 2005118548.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XII) 65809 (S)-2-(Methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate 871224-68-9 C16H17NO4S 详情 详情
(XV) 65811 (S)-(+)-Methyl mandelate; (+)-Methyl (S)-alpha-hydroxyphenylacetate 21210-43-5 C9H10O3 详情 详情
(XVI) 65812     C9H11NO2 详情 详情
Extended Information