合成路线1

In a different procedure, the potassium salt of tolevamer can be synthesized as follows. Chlorosulfonation of phenethyl bromide (V) with ClSO3H gives 4-(2-bromoethyl)benzenesulfonyl chloride (VI), which undergoes simultaneous elimination of HBr and sulfonyl chloride hydrolysis in boiling ethanolic KOH to furnish potassium 4-vinylbenzenesulfonate (VII). Subsequent polymerization of (VII) in DMF solution in the presence of tert-butyl peracetate as initiator gives rise to tolevamer potassium (4). Scheme 2.