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【结 构 式】

【分子编号】65364

【品名】 

【CA登记号】 

【 分 子 式 】C8H8BrClO2S

【 分 子 量 】283.57302

【元素组成】C 33.88% H 2.84% Br 28.18% Cl 12.5% O 11.28% S 11.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

In a different procedure, the potassium salt of tolevamer can be synthesized as follows. Chlorosulfonation of phenethyl bromide (V) with ClSO3H gives 4-(2-bromoethyl)benzenesulfonyl chloride (VI), which undergoes simultaneous elimination of HBr and sulfonyl chloride hydrolysis in boiling ethanolic KOH to furnish potassium 4-vinylbenzenesulfonate (VII). Subsequent polymerization of (VII) in DMF solution in the presence of tert-butyl peracetate as initiator gives rise to tolevamer potassium (4). Scheme 2.

4 Wiley, R.H., Reed, S.F., Jr. Sulfostyrenes. Polymers and copolymers of potassium p-vinylbenzenesulfonate. J Am Chem Soc 1956, 78(10): 2171-3.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 20730 1-(2-bromoethyl)benzene;1-Bromo-2-phenylethane;(2-Bromoethyl)benzene;Phenethyl bromide 103-63-9 C8H9Br 详情 详情
(VI) 65364     C8H8BrClO2S 详情 详情
(VII) 65365 Potassium 4-vinylbenzenesulfonate; Potassium pvinylbenzenesulphonate 26638-29-9 C8H7KO3S 详情 详情
Extended Information