【结 构 式】 |
【分子编号】65364 【品名】 【CA登记号】 |
【 分 子 式 】C8H8BrClO2S 【 分 子 量 】283.57302 【元素组成】C 33.88% H 2.84% Br 28.18% Cl 12.5% O 11.28% S 11.31% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VI)In a different procedure, the potassium salt of tolevamer can be synthesized as follows. Chlorosulfonation of phenethyl bromide (V) with ClSO3H gives 4-(2-bromoethyl)benzenesulfonyl chloride (VI), which undergoes simultaneous elimination of HBr and sulfonyl chloride hydrolysis in boiling ethanolic KOH to furnish potassium 4-vinylbenzenesulfonate (VII). Subsequent polymerization of (VII) in DMF solution in the presence of tert-butyl peracetate as initiator gives rise to tolevamer potassium (4). Scheme 2.
【4】 Wiley, R.H., Reed, S.F., Jr. Sulfostyrenes. Polymers and copolymers of potassium p-vinylbenzenesulfonate. J Am Chem Soc 1956, 78(10): 2171-3. |
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