3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-nonylpropanamide -Drug Synthesis Database

【结构式】

【分子编号】64801

【品名】3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-nonylpropanamide

【CA登记号】

【分子式】C₂₀H₂₈N₂O₃

【分子量】344.454

【元素组成】C 69.74% H 8.19% N 8.13% O 13.93%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

3-Phthalimidopropionyl chloride (I) is condensed with n-nonylamine to produce the corresponding amide (II). Subsequent hydrazinolysis of phthalimide (II) furnishes the aminopropanamide (III), which is condensed with D-pantonolactone (IV) to yield the desired compound.

参考文献中间体

合成目标

【1】 Clifton, G.; Bryant, S.R.; Skinner, C.G.; N1-(Substituted) pantothenamides, antimetabolites of pantothenic acid. Arch Biochem Biophys 1970, 137, 2, 523.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53390	3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl chloride	n/a	C₁₁H₈ClNO₃	详情	详情
(II)	64801	3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-nonylpropanamide		C₂₀H₂₈N₂O₃	详情	详情
(III)	64802	3-amino-N-nonylpropanamide		C₁₂H₂₆N₂O	详情	详情
(IV)	51427	D-Pantolactone; R(-)-2-Hydroxy-3,3-dimethyl-gamma-butyrolactone	599-04-2	C₆H₁₀O₃	详情	详情

Extended Information