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【结 构 式】 
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【药物名称】 【化学名称】2(R),4-Dihydroxy-3,3-dimethyl-N-[2-(N-nonylcarbamoyl)ethyl]butyramide 【CA登记号】25303-16-6 (undefined stereoch.) 【 分 子 式 】C18H36N2O4 【 分 子 量 】344.49862 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY |
合成路线1
3-Phthalimidopropionyl chloride (I) is condensed with n-nonylamine to produce the corresponding amide (II). Subsequent hydrazinolysis of phthalimide (II) furnishes the aminopropanamide (III), which is condensed with D-pantonolactone (IV) to yield the desired compound.
| 【1】 Clifton, G.; Bryant, S.R.; Skinner, C.G.; N1-(Substituted) pantothenamides, antimetabolites of pantothenic acid. Arch Biochem Biophys 1970, 137, 2, 523. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 53390 | 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl chloride | n/a | C11H8ClNO3 | 详情 | 详情 |
| (II) | 64801 | 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-nonylpropanamide | C20H28N2O3 | 详情 | 详情 | |
| (III) | 64802 | 3-amino-N-nonylpropanamide | C12H26N2O | 详情 | 详情 | |
| (IV) | 51427 | D-Pantolactone; R(-)-2-Hydroxy-3,3-dimethyl-gamma-butyrolactone | 599-04-2 | C6H10O3 | 详情 | 详情 |
Extended Information