methyl bis(methyloxy)(thioxo)-lambda~5~-phosphanecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】64758

【品名】methyl bis(methyloxy)(thioxo)-lambda~5~-phosphanecarboxylate

【CA登记号】

【分子式】C₄H₉O₄PS

【分子量】184.152822

【元素组成】C 26.09% H 4.93% O 34.75% P 16.82% S 17.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of phosphonoformic acid trimethyl ester (I) with Lawesson's reagent in refluxing acetonitrile gives the thiophosphonate (II), which is hydrolyzed with 10 N NaOH.

参考文献中间体

合成目标

【1】 McKenna, C.E.; Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid. US 5183812 .
【2】 McKenna, C.E.; Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid. US 5072032 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15993	Trimethyl phosphonoformate; Methyl dimethoxy(oxo)phosphoranecarboxylate	31142-23-1	C₄H₉O₅P	详情	详情
(II)	64758	methyl bis(methyloxy)(thioxo)-lambda~5~-phosphanecarboxylate		C₄H₉O₄PS	详情	详情

Extended Information