|
【结 构 式】 
|
【药物名称】TPFA, Thiovir 【化学名称】Hydroxy(sulfanyl)phosphinecarboxylic acid oxide 【CA登记号】102805-86-7, 99107-93-4 (triNa salt) 【 分 子 式 】CH3O4PS 【 分 子 量 】142.07046 |
【开发单位】University of Southern California (Originator), Adventrx Pharmaceuticals (Licensee), National Cancer Institute (Codevelopment) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Anti-Papilloma Virus Drugs, Antiviral Drugs, Cervical Cancer Therapy, Genital Warts, Treatment for, Oncolytic Drugs, Reverse Transcriptase Inhibitors |
合成路线1
The reaction of phosphonoformic acid trimethyl ester (I) with Lawesson's reagent in refluxing acetonitrile gives the thiophosphonate (II), which is hydrolyzed with 10 N NaOH.
| 【1】 McKenna, C.E.; Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid. US 5183812 . |
| 【2】 McKenna, C.E.; Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid. US 5072032 . |
Extended Information