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【结 构 式】 
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【分子编号】64684 【品名】(rac)-[(4R*,6S*)-6-{(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl}-4-hydroxytetrahydro-2H-pyran-2-one] 【CA登记号】 |
【 分 子 式 】C26H32FNO4 【 分 子 量 】441.5428232 【元素组成】C 70.73% H 7.3% F 4.3% N 3.17% O 14.49% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)In an alternative approach, the racemic dihydroxymethyl ester (IX) is converted to the racemic lactone (XI), which can be separated into the pure enantiomers on a large-scale chromatography using the newly developed chiral phase Baychiral PM. Finally, the (+)-lactone (XII) is hydrolyzed to BAY W 6228.
| 【1】 Angerbauer, R.; Bischoff, H.; Bömer, B.; Fey, P.; Grosser, R.; Hübsch, W.; Lange, W.; Lautz, J.; Philipps, T.; Schmidt, D.; Stereoselective biological activity of the synthetic HMG-CoA reductase inhibitor BAY W 6228. 2nd Eur Med Chem Conf (March 31-April 4, Bad Nauheim) 1993, 1993. |
| 【2】 Bischoff, H.; Ritter, W.; Steinke, W.; Angerbauer, R.; BAY W 6228. Drugs Fut 1994, 19, 6, 537. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 15884 | methyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoate | C27H36FNO5 | 详情 | 详情 | |
| (XI) | 64684 | (rac)-[(4R*,6S*)-6-{(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl}-4-hydroxytetrahydro-2H-pyran-2-one] | C26H32FNO4 | 详情 | 详情 | |
| (XII) | 15886 | (4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl]-4-hydroxytetrahydro-2H-pyran-2-one | C26H32FNO4 | 详情 | 详情 | |
| (XIII) | 15888 | (4S,6R)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl]-4-hydroxytetrahydro-2H-pyran-2-one | C26H32FNO4 | 详情 | 详情 |
Extended Information