(4S,6R)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl]-4-hydroxytetrahydro-2H-pyran-2-one -Drug Synthesis Database

【结构式】

【分子编号】15888

【品名】(4S,6R)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl]-4-hydroxytetrahydro-2H-pyran-2-one

【CA登记号】

【分子式】C₂₆H₃₂FNO₄

【分子量】441.5428232

【元素组成】C 70.73% H 7.3% F 4.3% N 3.17% O 14.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

In an alternative approach, the racemic dihydroxymethyl ester (IX) is converted to the racemic lactone (XI), which can be separated into the pure enantiomers on a large-scale chromatography using the newly developed chiral phase Baychiral PM. Finally, the (+)-lactone (XII) is hydrolyzed to BAY W 6228.

参考文献中间体

合成目标

【1】 Angerbauer, R.; Bischoff, H.; Bömer, B.; Fey, P.; Grosser, R.; Hübsch, W.; Lange, W.; Lautz, J.; Philipps, T.; Schmidt, D.; Stereoselective biological activity of the synthetic HMG-CoA reductase inhibitor BAY W 6228. 2nd Eur Med Chem Conf (March 31-April 4, Bad Nauheim) 1993, 1993.
【2】 Bischoff, H.; Ritter, W.; Steinke, W.; Angerbauer, R.; BAY W 6228. Drugs Fut 1994, 19, 6, 537.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IX)	15884	methyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoate	C₂₇H₃₆FNO₅	详情	详情
(XI)	64684	(rac)-[(4R,6S)-6-{(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl}-4-hydroxytetrahydro-2H-pyran-2-one]	C₂₆H₃₂FNO₄	详情	详情
(XII)	15886	(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl]-4-hydroxytetrahydro-2H-pyran-2-one	C₂₆H₃₂FNO₄	详情	详情
(XIII)	15888	(4S,6R)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]ethenyl]-4-hydroxytetrahydro-2H-pyran-2-one	C₂₆H₃₂FNO₄	详情	详情

Extended Information