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【结 构 式】 
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【分子编号】64585 【品名】(4-methoxybenzyl)(triphenyl)phosphonium bromide 【CA登记号】 |
【 分 子 式 】C26H24BrOP 【 分 子 量 】463.353722 【元素组成】C 67.4% H 5.22% Br 17.24% O 3.45% P 6.68% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)4-Methoxybenzyl bromide (I) is condensed with triphenylphosphine in refluxing toluene to produce the phosphonium salt (II). Subsequent Wittig condensation of (II) with 3,5-dimethoxybenzaldehyde (III) gives rise to a mixture of the title Z-stilbene and its E-isomer (IV), which can be separated by means of flash chromatography.
| 【1】 Pettit, G.R.; Grealish, M.P.; Jung, M.K.; Hamel, E.; Pettit, R.K.; Chapuis, J.-C.; Schmidt, J.M.; Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. J Med Chem 2002, 45, 12, 2534. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27490 | 1-(bromomethyl)-4-methoxybenzene | C8H9BrO | 详情 | 详情 | |
| (II) | 64585 | (4-methoxybenzyl)(triphenyl)phosphonium bromide | C26H24BrOP | 详情 | 详情 | |
| (III) | 21720 | 3,5-dimethoxybenzaldehyde | 7311-34-4 | C9H10O3 | 详情 | 详情 |
| (IV) | 62024 | 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenyl methyl ether; 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene | C17H18O3 | 详情 | 详情 |
Extended Information