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【结 构 式】

【药物名称】

【化学名称】cis-3,4',5-Trimethoxystilbene

【CA登记号】

【 分 子 式 】C17H18O3

【 分 子 量 】270.33121

【开发单位】Arizona State University (Originator), National Institutes of Health (Originator)

【药理作用】ONCOLYTIC DRUGS, Antimitotic Drugs, Microtubule-Stabilizing Agents

合成路线1

4-Methoxybenzyl bromide (I) is condensed with triphenylphosphine in refluxing toluene to produce the phosphonium salt (II). Subsequent Wittig condensation of (II) with 3,5-dimethoxybenzaldehyde (III) gives rise to a mixture of the title Z-stilbene and its E-isomer (IV), which can be separated by means of flash chromatography.

1 Pettit, G.R.; Grealish, M.P.; Jung, M.K.; Hamel, E.; Pettit, R.K.; Chapuis, J.-C.; Schmidt, J.M.; Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. J Med Chem 2002, 45, 12, 2534.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 27490 1-(bromomethyl)-4-methoxybenzene C8H9BrO 详情 详情
(II) 64585 (4-methoxybenzyl)(triphenyl)phosphonium bromide C26H24BrOP 详情 详情
(III) 21720 3,5-dimethoxybenzaldehyde 7311-34-4 C9H10O3 详情 详情
(IV) 62024 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenyl methyl ether; 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene C17H18O3 详情 详情
Extended Information