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【结 构 式】

【分子编号】64472

【品名】3-isocyanatobenzenesulfonyl fluoride

【CA登记号】

【 分 子 式 】C7H4FNO3S

【 分 子 量 】201.1781032

【元素组成】C 41.79% H 2% F 9.44% N 6.96% O 23.86% S 15.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

2-Aminothiazole (I) is coupled to 3-fluorosulfonylphenyl isocyanate (II) producing the diaryl urea (III). Subsequent reaction of sulfonyl fluoride (III) with tryptamine (IV) in hot acetonitrile furnishes the target sulfonamide.

1 Beyer, D.; Kroll, H.; Bauser, M.; Siegel, S.; Brotz, H.; Endermann, R.; Schiffer, G.; Ziegelbauer, K.; Habich, D.; Pohlmann, J.; Phenyl-thiazolylurea-sulfonamides as novel inhibitors of phenylalanine-tRNA synthetase. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-756.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19795 2-Thiazolamine; 1,3-thiazol-2-amine; 1,3-thiazol-2-ylamine 96-50-4 C3H4N2S 详情 详情
(II) 64472 3-isocyanatobenzenesulfonyl fluoride C7H4FNO3S 详情 详情
(III) 64473 3-{[(1,3-thiazol-2-ylamino)carbonyl]amino}benzenesulfonyl fluoride C10H8FN3O3S2 详情 详情
(IV) 40537 Tryptamine; 2-(1H-Indol-3-yl)-1-ethanamine; 2-(1H-Indol-3-yl)ethylamine 61-54-1 C10H12N2 详情 详情
Extended Information