N-(6-chrysenyl)-N-[(E)-phenylmethylidene]amine; N-[(E)-phenylmethylidene]-6-chrysenamine -Drug Synthesis Database

【结构式】

【分子编号】64398

【品名】N-(6-chrysenyl)-N-[(E)-phenylmethylidene]amine; N-[(E)-phenylmethylidene]-6-chrysenamine

【CA登记号】

【分子式】C₂₅H₁₇N

【分子量】331.41672

【元素组成】C 90.6% H 5.17% N 4.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title trans beta-lactam is obtained by condensation of imine (I) with acetyloxyacetyl chloride (II) in the presence of Et3N in cold CH2Cl2 under Staudinger reaction conditions. (1,2)

参考文献中间体

合成目标

【1】 Banik, N.K.; Becker, F.F.; Unprecedented stereoselectivity in the Staudinger reaction with polycyclic aromatic imines. Tetrahedron Lett 2000, 41, 34, 6551.
【2】 Banik, I.; Becker, F.F.; Banik, B.K.; Stereoselective synthesis of beta-lactams with polyaromatic imines: Entry to new and novel anticancer agents. J Med Chem 2003, 46, 1, 12.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	64398	N-(6-chrysenyl)-N-[(E)-phenylmethylidene]amine; N-[(E)-phenylmethylidene]-6-chrysenamine		C₂₅H₁₇N	详情	详情
(II)	10456	Acetoxiacetil chloride; 2-chloro-2-oxoethyl acetate	13831-31-7	C₄H₅ClO₃	详情	详情

Extended Information