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【结 构 式】 
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【药物名称】 【化学名称】Acetic acid trans-1-(6-chrysenyl)-2-oxo-4-phenylazetidin-3-yl ester 【CA登记号】302595-58-0 【 分 子 式 】C29H21NO3 【 分 子 量 】431.49562 |
【开发单位】M.D. Anderson Cancer Center (Originator) 【药理作用】ONCOLYTIC DRUGS, beta-Lactams |
合成路线1
The title trans beta-lactam is obtained by condensation of imine (I) with acetyloxyacetyl chloride (II) in the presence of Et3N in cold CH2Cl2 under Staudinger reaction conditions. (1,2)
| 【1】 Banik, N.K.; Becker, F.F.; Unprecedented stereoselectivity in the Staudinger reaction with polycyclic aromatic imines. Tetrahedron Lett 2000, 41, 34, 6551. |
| 【2】 Banik, I.; Becker, F.F.; Banik, B.K.; Stereoselective synthesis of beta-lactams with polyaromatic imines: Entry to new and novel anticancer agents. J Med Chem 2003, 46, 1, 12. |
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