【结 构 式】 |
【分子编号】63952 【品名】diisopropyl (2-iodo-1,1-dimethylethoxy)methylphosphonate 【CA登记号】 |
【 分 子 式 】C11H24IO4P 【 分 子 量 】378.187392 【元素组成】C 34.94% H 6.4% I 33.56% O 16.92% P 8.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Reaction of isobutene (I) and diisopropyl phosphonylmethanol (II) in the presence of IBr as an electrophile afforded the phosphonate (III), which was converted to the desired 9-[2-methyl-2-(phosphonomethoxy)propyl]guanine (2',2'-dimethyl-PMEG).
【1】 Hwang, J.-T.; Choi, J.-R.; Novel phosphonate nucleosides as antiviral agents. Drugs Fut 2004, 29, 2, 163. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 15926 | 2-methyl-1-propene; isobutylene | 115-11-7 | C4H8 | 详情 | 详情 |
(II) | 63951 | diisopropyl hydroxymethylphosphonate | C7H17O4P | 详情 | 详情 | |
(III) | 63952 | diisopropyl (2-iodo-1,1-dimethylethoxy)methylphosphonate | C11H24IO4P | 详情 | 详情 | |
(IV) | 63953 | 2-amino-9-chloro-1,9-dihydro-6H-purin-6-one | C5H4ClN5O | 详情 | 详情 |
Extended Information