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【结 构 式】 
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【药物名称】2', 2'-Dimethyl-PMEG 【化学名称】9-[2-Methyl-2-(phosphonomethoxy)propyl]guanine 【CA登记号】 【 分 子 式 】C10H16N5O5P 【 分 子 量 】317.24332 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY |
合成路线1
Reaction of isobutene (I) and diisopropyl phosphonylmethanol (II) in the presence of IBr as an electrophile afforded the phosphonate (III), which was converted to the desired 9-[2-methyl-2-(phosphonomethoxy)propyl]guanine (2',2'-dimethyl-PMEG).
| 【1】 Hwang, J.-T.; Choi, J.-R.; Novel phosphonate nucleosides as antiviral agents. Drugs Fut 2004, 29, 2, 163. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15926 | 2-methyl-1-propene; isobutylene | 115-11-7 | C4H8 | 详情 | 详情 |
| (II) | 63951 | diisopropyl hydroxymethylphosphonate | C7H17O4P | 详情 | 详情 | |
| (III) | 63952 | diisopropyl (2-iodo-1,1-dimethylethoxy)methylphosphonate | C11H24IO4P | 详情 | 详情 | |
| (IV) | 63953 | 2-amino-9-chloro-1,9-dihydro-6H-purin-6-one | C5H4ClN5O | 详情 | 详情 |
Extended Information