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【结 构 式】 
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【分子编号】63827 【品名】1-iodo-2,5-pyrrolidinedione 【CA登记号】 |
【 分 子 式 】C4H4INO2 【 分 子 量 】224.98577 【元素组成】C 21.35% H 1.79% I 56.41% N 6.23% O 14.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：Alternative preparation of the key intermediote (XIII)
| 【1】 Harrington, P.M.; Shih, C.; Grindey, G.B.; Gossett, L.S.; Moran, R.G.; Taylor, S.C.; Synthesis and structure-activity relationship studies of 5,10-dideazatetrahydrofolic acid (DDATHF). Chemistry and Biology of Pteridines (1989): Pteridines and Folic Acid Derivatives. H.-C. Curtius, S. Ghisla and N. Blau (Eds.). de Gruyter, New York 1990, 1035. |
| 【2】 Taylor, E.C.; Wong, G.S.K.; Convergent and efficient palladium-effected synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF). J Org Chem 1989, 54, 15, 3618. |
| 【3】 Castaner, J.; Prous, J.; Lometrexol. Drugs Fut 1993, 18, 2, 121. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 | |
| 63827 | 1-iodo-2,5-pyrrolidinedione | C4H4INO2 | 详情 | 详情 | ||
| (XVI) | 14292 | methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate | C7H7NO3 | 详情 | 详情 | |
| (XVII) | 14293 | methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate | C7H6INO3 | 详情 | 详情 | |
| (XVIII) | 14294 | methyl 2-chloro-5-iodonicotinate | C7H5ClINO2 | 详情 | 详情 | |
| (XIX) | 14285 | tert-butyl 4-ethynylbenzoate | C13H14O2 | 详情 | 详情 | |
| (XX) | 14296 | methyl 5-[2-[4-(tert-butoxycarbonyl)phenyl]ethynyl]-2-chloronicotinate | C20H18ClNO4 | 详情 | 详情 | |
| (XXI) | 14297 | tert-butyl 4-[2-(2-amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethynyl]benzoate | C20H18N4O3 | 详情 | 详情 | |
| (XXII) | 14298 | 4-[2-(2-Amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethynyl]benzoic acid | C16H10N4O3 | 详情 | 详情 |
Extended Information