tert-butyl 4-[2-(2-amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethynyl]benzoate -Drug Synthesis Database

【结构式】

【分子编号】14297

【品名】tert-butyl 4-[2-(2-amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethynyl]benzoate

【CA登记号】

【分子式】C₂₀H₁₈N₄O₃

【分子量】362.38808

【元素组成】C 66.29% H 5.01% N 15.46% O 13.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXI)

Alternative preparation of the key intermediote (XIII)

【1】 Harrington, P.M.; Shih, C.; Grindey, G.B.; Gossett, L.S.; Moran, R.G.; Taylor, S.C.; Synthesis and structure-activity relationship studies of 5,10-dideazatetrahydrofolic acid (DDATHF). Chemistry and Biology of Pteridines (1989): Pteridines and Folic Acid Derivatives. H.-C. Curtius, S. Ghisla and N. Blau (Eds.). de Gruyter, New York 1990, 1035.
【2】 Taylor, E.C.; Wong, G.S.K.; Convergent and efficient palladium-effected synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF). J Org Chem 1989, 54, 15, 3618.
【3】 Castaner, J.; Prous, J.; Lometrexol. Drugs Fut 1993, 18, 2, 121.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	14790	Guanidine	113-00-8	CH₅N₃	详情	详情
	63827	1-iodo-2,5-pyrrolidinedione		C₄H₄INO₂	详情	详情
(XVI)	14292	methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate		C₇H₇NO₃	详情	详情
(XVII)	14293	methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate		C₇H₆INO₃	详情	详情
(XVIII)	14294	methyl 2-chloro-5-iodonicotinate		C₇H₅ClINO₂	详情	详情
(XIX)	14285	tert-butyl 4-ethynylbenzoate		C₁₃H₁₄O₂	详情	详情
(XX)	14296	methyl 5-[2-[4-(tert-butoxycarbonyl)phenyl]ethynyl]-2-chloronicotinate		C₂₀H₁₈ClNO₄	详情	详情
(XXI)	14297	tert-butyl 4-[2-(2-amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethynyl]benzoate		C₂₀H₁₈N₄O₃	详情	详情
(XXII)	14298	4-[2-(2-Amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethynyl]benzoic acid		C₁₆H₁₀N₄O₃	详情	详情

Extended Information