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【结 构 式】 
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【分子编号】63663 【品名】methyl 1-hydroxy-2,2,5,5-tetramethyl-3-pyrrolidinecarboxylate 【CA登记号】 |
【 分 子 式 】C10H19NO3 【 分 子 量 】201.2658 【元素组成】C 59.68% H 9.52% N 6.96% O 23.85% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Bubbling dry HCl through a methanol solution of 1-oxyl-3-carboxy-2,2,5,5-tetramethylpyrrolidine (I) for a short period of time leads to the nitroxide radical methyl ester (II). Reduction of (II) to the hydroxylamine (III) is then accomplished by treatment with hydrazine in MeOH. Alternatively, upon treatment of (I) with HCl/MeOH for longer than 24 h, this undergoes both esterification and reduction to the hydroxylamine methyl ester (III). Further acetylation of hydroxylamine (III) by using Ac2O in the presence of Et3N yields the title compound.
| 【1】 Yordanov, A.T.; Yamada, K.-i.; Krishna, M.C.; Russo, A.; Yoo, J.; English, S.; Mitchell, J.B.; Brechbiel, M.W.; Acyl-protected hydroxylamines as spin label generators for EPR brain imaging. J Med Chem 2002, 45, 11, 2283. |
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