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【结 构 式】 
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【药物名称】AMCPy 【化学名称】1-Acetoxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid methyl ester 【CA登记号】3521-56-8 【 分 子 式 】C12H21NO4 【 分 子 量 】243.30547 |
【开发单位】National Institutes of Health (Originator) 【药理作用】DIAGNOSTIC AGENTS |
合成路线1
Bubbling dry HCl through a methanol solution of 1-oxyl-3-carboxy-2,2,5,5-tetramethylpyrrolidine (I) for a short period of time leads to the nitroxide radical methyl ester (II). Reduction of (II) to the hydroxylamine (III) is then accomplished by treatment with hydrazine in MeOH. Alternatively, upon treatment of (I) with HCl/MeOH for longer than 24 h, this undergoes both esterification and reduction to the hydroxylamine methyl ester (III). Further acetylation of hydroxylamine (III) by using Ac2O in the presence of Et3N yields the title compound.
| 【1】 Yordanov, A.T.; Yamada, K.-i.; Krishna, M.C.; Russo, A.; Yoo, J.; English, S.; Mitchell, J.B.; Brechbiel, M.W.; Acyl-protected hydroxylamines as spin label generators for EPR brain imaging. J Med Chem 2002, 45, 11, 2283. |