2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)-1-propanone -Drug Synthesis Database

【结构式】

【分子编号】63661

【品名】2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)-1-propanone

【CA登记号】

【分子式】C₉H₈ClNO₅

【分子量】245.61896

【元素组成】C 44.01% H 3.28% Cl 14.43% N 5.7% O 32.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title compound is prepared by condensation between 2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)ethanone (I) and 1-(3-trifluoromethylphenyl)piperazine (II) in DMF, followed by conversion to the corresponding dihydrochloride salt.

参考文献中间体

合成目标

【1】 Learmonth, D.A.; Soares Da Silva, P.M.V.A. (Portela & Ca., SA); Novel substd. nitrocatechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compsns. containing them. EP 1167342; WO 0198251 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63661	2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)-1-propanone		C₉H₈ClNO₅	详情	详情
(II)	16172	1-[3-(trifluoromethyl)phenyl]piperazine; N-[3-(trifluoromethyl)phenyl]piperazine	15532-75-9	C₁₁H₁₃F₃N₂	详情	详情

Extended Information