BIA-3-335, -Drug Synthesis Database

【结构式】

【药物名称】BIA-3-335

【化学名称】1-(3,4-Dihydroxy-5-nitrophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one dihydrochloride

【CA登记号】359783-06-5

【分子式】C₂₀H₂₂Cl₂F₃N₃O₅

【分子量】512.31664

【开发单位】Bial (Originator), Portela (Originator)

【药理作用】Antidepressants, Antiparkinsonian Drugs, Extrapyramidal Disorders, Treatment of, Mood Disorders, Treatment of, NEUROLOGIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, COMT Inhibitors

合成路线1

The title compound is prepared by condensation between 2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)ethanone (I) and 1-(3-trifluoromethylphenyl)piperazine (II) in DMF, followed by conversion to the corresponding dihydrochloride salt.

参考文献中间体

【1】 Learmonth, D.A.; Soares Da Silva, P.M.V.A. (Portela & Ca., SA); Novel substd. nitrocatechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compsns. containing them. EP 1167342; WO 0198251 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63661	2-chloro-1-(3,4-dihydroxy-5-nitrophenyl)-1-propanone		C₉H₈ClNO₅	详情	详情
(II)	16172	1-[3-(trifluoromethyl)phenyl]piperazine; N-[3-(trifluoromethyl)phenyl]piperazine	15532-75-9	C₁₁H₁₃F₃N₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)