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【结 构 式】 
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【分子编号】63649 【品名】2-aminocyclopentanol 【CA登记号】 |
【 分 子 式 】C5H11NO 【 分 子 量 】101.14848 【元素组成】C 59.37% H 10.96% N 13.85% O 15.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(rac)-(II)This compound has been obtained by two similar ways: 1) By condensation of the chloropurine (I) with (1S-trans)-2-aminocyclopentanol (1S-trans)-(II) by means of DEA in refluxing isopropanol. 2) The condensation of chloropurine (I) with (rac-trans)-2-aminocyclopentanol (rac-trans)-(II) (obtained by reaction of cyclopentene oxide (III) with ammonia) give a diastereomeric mixture, from which the target compound can be isolated by flash chromatography.
| 【1】 Evans, B. (Glaxo Wellcome plc); Adenosine derivs.. AU 8827401; BE 1002167; CH 677495; DE 3843609; EP 0322242; FR 2663936; US 5032583 . |
| 【2】 Knutsen, L.J.S.; Lau, J. (Novo Nordisk A/S); Purine derivs.. US 5672588 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (1S-trans)-(II) | 38010 | (1S,2S)-2-aminocyclopentanol | C5H11NO | 详情 | 详情 | |
| (rac)-(II) | 63649 | 2-aminocyclopentanol | C5H11NO | 详情 | 详情 | |
| (I) | 18716 | 6-chloropurine riboside; (2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol | 2004-06-0 | C10H11ClN4O4 | 详情 | 详情 |
| (III) | 38011 | 6-oxabicyclo[3.1.0]hexane | 285-67-6 | C5H8O | 详情 | 详情 |
Extended Information