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【结 构 式】 
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【分子编号】63499 【品名】4-(phenylmethyl)-3-{[1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinyl]carbonyl}-1,3-oxazolidin-2-one 【CA登记号】 |
【 分 子 式 】C26H26N2O3S 【 分 子 量 】446.57012 【元素组成】C 69.93% H 5.87% N 6.27% O 10.75% S 7.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Acid-catalyzed cycloaddition of the chiral acryloyl oxazolidine derivative (I) with amine (II) affords a diastereomeric mixture of trans pyrrolidines (III) and (IV). The desired isomer (IV) is then reduced by DIBAL to the intermediate aldehyde (V)
| 【1】 Pyrrolidine antagonists of the CCR3 chemokine receptor. 225th ACS Natl Meet (March 23 2003, New Orleans) 2003, Abst MEDI 250. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63496 | 4-(phenylmethyl)-3-[3-(3-thiophenyl)acryloyl]-1,3-oxazolidin-2-one | C17H15NO3S | 详情 | 详情 | |
| (II) | 25556 | N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; N-benzyl-N-(methoxymethyl)(trimethylsilyl)methanamine | 1871-96-1 | C13H23NOSi | 详情 | 详情 |
| (III) | 63498 | 4-(phenylmethyl)-3-{[1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinyl]carbonyl}-1,3-oxazolidin-2-one | C26H26N2O3S | 详情 | 详情 | |
| (IV) | 63499 | 4-(phenylmethyl)-3-{[1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinyl]carbonyl}-1,3-oxazolidin-2-one | C26H26N2O3S | 详情 | 详情 | |
| (V) | 63500 | 1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinecarbaldehyde | C16H17NOS | 详情 | 详情 |
Extended Information