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【结 构 式】

【分子编号】63498

【品名】4-(phenylmethyl)-3-{[1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinyl]carbonyl}-1,3-oxazolidin-2-one

【CA登记号】

【 分 子 式 】C26H26N2O3S

【 分 子 量 】446.57012

【元素组成】C 69.93% H 5.87% N 6.27% O 10.75% S 7.18%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Acid-catalyzed cycloaddition of the chiral acryloyl oxazolidine derivative (I) with amine (II) affords a diastereomeric mixture of trans pyrrolidines (III) and (IV). The desired isomer (IV) is then reduced by DIBAL to the intermediate aldehyde (V)

1 Pyrrolidine antagonists of the CCR3 chemokine receptor. 225th ACS Natl Meet (March 23 2003, New Orleans) 2003, Abst MEDI 250.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 63496 4-(phenylmethyl)-3-[3-(3-thiophenyl)acryloyl]-1,3-oxazolidin-2-one C17H15NO3S 详情 详情
(II) 25556 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; N-benzyl-N-(methoxymethyl)(trimethylsilyl)methanamine 1871-96-1 C13H23NOSi 详情 详情
(III) 63498 4-(phenylmethyl)-3-{[1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinyl]carbonyl}-1,3-oxazolidin-2-one C26H26N2O3S 详情 详情
(IV) 63499 4-(phenylmethyl)-3-{[1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinyl]carbonyl}-1,3-oxazolidin-2-one C26H26N2O3S 详情 详情
(V) 63500 1-(phenylmethyl)-4-(3-thiophenyl)-3-pyrrolidinecarbaldehyde C16H17NOS 详情 详情
Extended Information