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【结 构 式】 
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【分子编号】63325 【品名】3-phenoxybenzaldehyde 【CA登记号】 |
【 分 子 式 】C13H10O2 【 分 子 量 】198.2212 【元素组成】C 78.77% H 5.08% O 16.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reductive alkylation of (S)-1,2,3,4-tetrahydro-1-naphthalenylamine (I) with 3-phenoxybenzaldehyde (II) in the presence of NaBH4 affords the secondary amine (III), which is then acylated with 1,2,4,5-benzenetetracarboxylic dianhydride (IV), followed by aqueous hydrolysis to furnish the title compound.
| 【1】 Lee, C.-H.; Stewart, A.O.; Perner, R.J.; Zheng, G.Z.; Larson, D.P.; Koenig, J.R.; Gomtsyan, A.R.; Didomenico, S.; Bayburt, E.K. (Abbott Laboratories Inc.); Trisubstd.-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors. US 2002173665; WO 0294767 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63324 | (1S)-1,2,3,4-tetrahydro-1-naphthalenamine; (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine | C10H13N | 详情 | 详情 | |
| (II) | 63325 | 3-phenoxybenzaldehyde | C13H10O2 | 详情 | 详情 | |
| (III) | 63326 | (1S)-N-(3-phenoxybenzyl)-1,2,3,4-tetrahydro-1-naphthalenamine; N-(3-phenoxybenzyl)-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amine | C23H23NO | 详情 | 详情 | |
| (IV) | 41484 | 1H,3H-furo[3,4-f][2]benzofuran-1,3,5,7-tetrone | 89-32-7 | C10H2O6 | 详情 | 详情 |
Extended Information