(1S)-N-(3-phenoxybenzyl)-1,2,3,4-tetrahydro-1-naphthalenamine; N-(3-phenoxybenzyl)-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amine -Drug Synthesis Database

【结构式】

【分子编号】63326

【品名】(1S)-N-(3-phenoxybenzyl)-1,2,3,4-tetrahydro-1-naphthalenamine; N-(3-phenoxybenzyl)-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amine

【CA登记号】

【分子式】C₂₃H₂₃NO

【分子量】329.44176

【元素组成】C 83.85% H 7.04% N 4.25% O 4.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reductive alkylation of (S)-1,2,3,4-tetrahydro-1-naphthalenylamine (I) with 3-phenoxybenzaldehyde (II) in the presence of NaBH4 affords the secondary amine (III), which is then acylated with 1,2,4,5-benzenetetracarboxylic dianhydride (IV), followed by aqueous hydrolysis to furnish the title compound.

参考文献中间体

合成目标

【1】 Lee, C.-H.; Stewart, A.O.; Perner, R.J.; Zheng, G.Z.; Larson, D.P.; Koenig, J.R.; Gomtsyan, A.R.; Didomenico, S.; Bayburt, E.K. (Abbott Laboratories Inc.); Trisubstd.-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors. US 2002173665; WO 0294767 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63324	(1S)-1,2,3,4-tetrahydro-1-naphthalenamine; (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine		C₁₀H₁₃N	详情	详情
(II)	63325	3-phenoxybenzaldehyde		C₁₃H₁₀O₂	详情	详情
(III)	63326	(1S)-N-(3-phenoxybenzyl)-1,2,3,4-tetrahydro-1-naphthalenamine; N-(3-phenoxybenzyl)-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amine		C₂₃H₂₃NO	详情	详情
(IV)	41484	1H,3H-furo[3,4-f][2]benzofuran-1,3,5,7-tetrone	89-32-7	C₁₀H₂O₆	详情	详情

Extended Information