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【结 构 式】 
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【分子编号】63200 【品名】N-(5-fluoro-2-phenoxyphenyl)-N-(2-hydroxy-5-methoxybenzyl)acetamide 【CA登记号】 |
【 分 子 式 】C22H20FNO4 【 分 子 量 】381.4035432 【元素组成】C 69.28% H 5.29% F 4.98% N 3.67% O 16.78% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(III)Reaction of diiodomethane (I) with [18F]fluoride at 100 C leads to the radiolabeled fluoromethyl iodide (II). The known peripheral benzodiazepine receptor ligand (III) is then alkylated with iodide (II) in the presence of NaH in DMF to furnish the title compound.
| 【1】 Zhang, M.-R.; Maeda, J.; Furutsuka, K.; Yoshida, Y.; Ogawa, M.; Suhara, T.; Suzuki, K.; [18F]FMDAA1106 and [18F]FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). Bioorg Med Chem Lett 2003, 13, 2, 201. |
合成路线2
该中间体在本合成路线中的序号：(III)Reaction of 2-bromoethyl triflate (I) with [18F]fluoride in boiling o-dichlorobenzene leads to the radiolabeled 1-bromo-2-fluoroethane (II). The known peripheral benzodiazepine receptor ligand (III) is then alkylated with bromide (II) in the presence of NaH in hot DMF to furnish the title compound.
| 【1】 Zhang, M.-R.; Maeda, J.; Furutsuka, K.; Yoshida, Y.; Ogawa, M.; Suhara, T.; Suzuki, K.; [18F]FMDAA1106 and [18F]FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). Bioorg Med Chem Lett 2003, 13, 2, 201. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63201 | 2-bromoethyl trifluoromethanesulfonate | C3H4BrF3O3S | 详情 | 详情 | |
| (II) | 28769 | 1-bromo-2-fluoroethane | 762-49-2 | C2H4BrF | 详情 | 详情 |
| (II) | 63202 | 1-bromo-2-fluoroethane | C2H4BrF | 详情 | 详情 | |
| (III) | 63200 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-hydroxy-5-methoxybenzyl)acetamide | C22H20FNO4 | 详情 | 详情 |
Extended Information