|
【结 构 式】 
|
【药物名称】[18F]-FEDAA-1106 【化学名称】N-[2-(2-[18-F]-Fluoroethoxy)-5-methoxybenzyl]-N-(5-fluoro-2-phenoxyphenyl)acetamide 【CA登记号】 【 分 子 式 】C24H23F2NO4 【 分 子 量 】426.45361 |
【开发单位】Japan Science and Technology (Originator), National Institute Radiological Sciences (Originator) 【药理作用】Diagnostic Agents, Drugs Acting on GABA-Mediated Transmission |
合成路线1
Reaction of 2-bromoethyl triflate (I) with [18F]fluoride in boiling o-dichlorobenzene leads to the radiolabeled 1-bromo-2-fluoroethane (II). The known peripheral benzodiazepine receptor ligand (III) is then alkylated with bromide (II) in the presence of NaH in hot DMF to furnish the title compound.
| 【1】 Zhang, M.-R.; Maeda, J.; Furutsuka, K.; Yoshida, Y.; Ogawa, M.; Suhara, T.; Suzuki, K.; [18F]FMDAA1106 and [18F]FEDAA1106: Two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). Bioorg Med Chem Lett 2003, 13, 2, 201. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63201 | 2-bromoethyl trifluoromethanesulfonate | C3H4BrF3O3S | 详情 | 详情 | |
| (II) | 28769 | 1-bromo-2-fluoroethane | 762-49-2 | C2H4BrF | 详情 | 详情 |
| (II) | 63202 | 1-bromo-2-fluoroethane | C2H4BrF | 详情 | 详情 | |
| (III) | 63200 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-hydroxy-5-methoxybenzyl)acetamide | C22H20FNO4 | 详情 | 详情 |
Extended Information