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【结 构 式】

【分子编号】62822

【品名】methyl (2S)-3-[1,1'-biphenyl]-4-yl-2-[({1-[(tert-butoxycarbonyl)amino]cyclopentyl}carbonyl)amino]propanoate

【CA登记号】

【 分 子 式 】C27H34N2O5

【 分 子 量 】466.57744

【元素组成】C 69.51% H 7.34% N 6% O 17.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

Cycloleucine (I) is esterified with HCl/MeOH, and the resultant amino ester (II) is further protected as the tert-butyl carbamate (III) employing Boc2O and Et3N in CH2Cl2. Then, hydrolysis of the methyl ester group of (III) with LiOH furnishes N-Boc-cycloleucine (IV). N-Boc-L-Biphenylalanine (V) is simultaneously deprotected and esterified with HCl/MeOH to yield amino ester (VI). Coupling between N-Boc-cycloleucine (IV) and L-biphenylalanine methyl ester (VI) in the presence of EDC/HOAt gives rise to the protected dipeptide (VII). Subsequent removal of the N-Boc group of (VII) under acidic conditions yields the dipeptide methyl ester (VIII).

1 Fink, C.A.; De Lombaert, S.; Hoyer, D.W.; Jeng, A.Y.; Firoozina, F. (Novartis AG; Novartis Pharma GmbH); Certain thiol inhibitors of endothelin-converting enzyme. WO 9955726 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 33149 1-aminocyclopentanecarboxylic acid 52-52-8 C6H11NO2 详情 详情
(II) 10444 methyl 1-aminocyclopentanecarboxylate C7H13NO2 详情 详情
(III) 62819 methyl 1-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylate C12H21NO4 详情 详情
(IV) 30890 1-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid C11H19NO4 详情 详情
(V) 62820 (2S)-3-[1,1'-biphenyl]-4-yl-2-[(tert-butoxycarbonyl)amino]propanoic acid C20H23NO4 详情 详情
(VI) 62821 methyl (2S)-2-amino-3-[1,1'-biphenyl]-4-ylpropanoate C16H17NO2 详情 详情
(VII) 62822 methyl (2S)-3-[1,1'-biphenyl]-4-yl-2-[({1-[(tert-butoxycarbonyl)amino]cyclopentyl}carbonyl)amino]propanoate C27H34N2O5 详情 详情
(VIII) 62823 methyl (2S)-2-{[(1-aminocyclopentyl)carbonyl]amino}-3-[1,1'-biphenyl]-4-ylpropanoate C22H26N2O3 详情 详情
Extended Information