N,6-dimethyl-2-pyridinecarboxamide -Drug Synthesis Database

【结构式】

【分子编号】62759

【品名】N,6-dimethyl-2-pyridinecarboxamide

【CA登记号】

【分子式】C₈H₁₀N₂O

【分子量】150.18028

【元素组成】C 63.98% H 6.71% N 18.65% O 10.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

6-Methylpicolinic acid (I) is esterified with MeOH and H2SO4, and the resultant methyl ester (II) is further reacted with methylamine to afford amide (III). The target zinc complex is then obtained by treatment of picolinamide (III) with an aqueous solution of ZnSO4.

参考文献中间体

合成目标

【1】 Ueda, E.; Yoshikawa, Y.; Ishino, Y.; Sakurai, H.; Kojima, Y.; Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: Preparations of complexes, in vitro and in vivo studies. Chem Pharm Bull 2002, 50, 3, 337.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30380	6-methyl-2-pyridinecarboxylic acid	934-60-1	C₇H₇NO₂	详情	详情
(II)	62758	methyl 6-methyl-2-pyridinecarboxylate	13602-11-4	C₈H₉NO₂	详情	详情
(III)	62759	N,6-dimethyl-2-pyridinecarboxamide		C₈H₁₀N₂O	详情	详情

Extended Information