Zn(6mpa-ma)2SO4, -Drug Synthesis Database

【结构式】

【药物名称】Zn(6mpa-ma)2SO4

【化学名称】Bis(N,6-dimethylpyridine-2-carboxamide)zinc sulfate

【CA登记号】

【分子式】C₁₆H₂₀N₄O₆SZn

【分子量】461.795

【开发单位】Kyoto Pharmaceutical University (Originator), Osaka City University (Originator), Osaka Municipal Technical Res. Institute (Originator)

【药理作用】Antidiabetic Drugs, ENDOCRINE DRUGS, Insulin Analogs, Zinc Complexes

合成路线1

6-Methylpicolinic acid (I) is esterified with MeOH and H2SO4, and the resultant methyl ester (II) is further reacted with methylamine to afford amide (III). The target zinc complex is then obtained by treatment of picolinamide (III) with an aqueous solution of ZnSO4.

参考文献中间体

【1】 Ueda, E.; Yoshikawa, Y.; Ishino, Y.; Sakurai, H.; Kojima, Y.; Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: Preparations of complexes, in vitro and in vivo studies. Chem Pharm Bull 2002, 50, 3, 337.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30380	6-methyl-2-pyridinecarboxylic acid	934-60-1	C₇H₇NO₂	详情	详情
(II)	62758	methyl 6-methyl-2-pyridinecarboxylate	13602-11-4	C₈H₉NO₂	详情	详情
(III)	62759	N,6-dimethyl-2-pyridinecarboxamide		C₈H₁₀N₂O	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)