N,N-dimethyl-2-[4-(3-methyl-2-thienyl)phenyl]alanine -Drug Synthesis Database

【结构式】

【分子编号】62698

【品名】N,N-dimethyl-2-[4-(3-methyl-2-thienyl)phenyl]alanine

【CA登记号】

【分子式】C₁₆H₁₉NO₂S

【分子量】289.3984

【元素组成】C 66.41% H 6.62% N 4.84% O 11.06% S 11.08%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXIV)

In an alternative procedure, acetophenone (XIV) was condensed with KCN in the presence of ammonium carbonate to produce hydantoin (XXII). Basic hydrolysis of (XXII) led to amino acid (XXIII), which was converted to the dimethylamino analogue (XXIV) by reductive alkylation under Eschweiler-Clarke conditions. The desired arylpropionic acid (IX) was obtained from (XXIV) by hydrogenolysis in the presence of Pd/C

参考文献中间体

合成目标

【2】 Arai, H.; Tanaka, K.; Watanabe, I.; Kodama, T.; Hirano, H.; Abe, N.; Nakabayashi, M. (Toyama Chemical Co., Ltd.); Novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and pharmaceutically acceptable salt thereof and method for treating symptoms of inflammation and pain. US 4230719 .
【1】 Kodama, T.; Nakabayashi, M.; Watanabe, I.; Hirano, Y.; Abe, N.; Tanaka, K.; Arai, H. (Toyama Chemical Co., Ltd.); 2-[4-(3-Methyl-2-thienyl)phenyl]propionic acid derivs. and its non-toxic salts. DE 2850485; JP 1981049376 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IX)	62687	2-[4-(3-methyl-2-thienyl)phenyl]propanoic acid	C₁₄H₁₄O₂S	详情	详情
(XIV)	62689	1-[4-(3-methyl-2-thienyl)phenyl]-1-ethanone	C₁₃H₁₂OS	详情	详情
(XXII)	62696	5-methyl-5-[4-(3-methyl-2-thienyl)phenyl]-2,4-imidazolidinedione	C₁₅H₁₄N₂O₂S	详情	详情
(XXIII)	62697	2-[4-(3-methyl-2-thienyl)phenyl]alanine	C₁₄H₁₅NO₂S	详情	详情
(XXIV)	62698	N,N-dimethyl-2-[4-(3-methyl-2-thienyl)phenyl]alanine	C₁₆H₁₉NO₂S	详情	详情

Extended Information