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【结 构 式】 
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【分子编号】62693 【品名】methyl 2,3-dimethyl-3-[4-(3-methyl-2-thienyl)phenyl]-2-oxiranecarboxylate 【CA登记号】 |
【 分 子 式 】C17H18O3S 【 分 子 量 】302.39412 【元素组成】C 67.52% H 6% O 15.87% S 10.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIX)Alternatively, Darzen's condensation of acetophenone (XIV) with methyl 2-chloropropionate (XVIII) produced glycidic ester (XIX), which was hydrolyzed and decarboxylated to the 3-arylbutanone (XX). The haloform reaction of ketone (XX) with sodium hypobromite generated acid (IX)
| 【2】 Arai, H.; Tanaka, K.; Watanabe, I.; Kodama, T.; Hirano, H.; Abe, N.; Nakabayashi, M. (Toyama Chemical Co., Ltd.); Novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and pharmaceutically acceptable salt thereof and method for treating symptoms of inflammation and pain. US 4230719 . |
| 【1】 Kodama, T.; Nakabayashi, M.; Watanabe, I.; Hirano, Y.; Abe, N.; Tanaka, K.; Arai, H. (Toyama Chemical Co., Ltd.); 2-[4-(3-Methyl-2-thienyl)phenyl]propionic acid derivs. and its non-toxic salts. DE 2850485; JP 1981049376 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 62687 | 2-[4-(3-methyl-2-thienyl)phenyl]propanoic acid | C14H14O2S | 详情 | 详情 | |
| (XIV) | 62689 | 1-[4-(3-methyl-2-thienyl)phenyl]-1-ethanone | C13H12OS | 详情 | 详情 | |
| (XVIII) | 35742 | methyl (2S)-2-chloropropanoate | C4H7ClO2 | 详情 | 详情 | |
| (XIX) | 62693 | methyl 2,3-dimethyl-3-[4-(3-methyl-2-thienyl)phenyl]-2-oxiranecarboxylate | C17H18O3S | 详情 | 详情 | |
| (XX) | 62694 | 3-[4-(3-methyl-2-thienyl)phenyl]-2-butanone | C15H16OS | 详情 | 详情 |
Extended Information