2-bromo-1-hexadecanol -Drug Synthesis Database

【结构式】

【分子编号】61881

【品名】2-bromo-1-hexadecanol

【CA登记号】

【分子式】C₁₆H₃₃BrO

【分子量】321.34142

【元素组成】C 59.8% H 10.35% Br 24.87% O 4.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

In a related procedure, halogenation of 1-hexadecene (I) with N-bromosuccinimide in THF/H2O leads to a mixture of regioisomeric bromohydrins (II) and (III). Refluxing of this mixture of bromohydrins with N,N-dimethyl ethanolamine (IV) in MeOH gives rise to the title ammonium salt as the only isomer.

参考文献中间体

合成目标

【1】 Wong, Y.-L.; et al.; Spermicidal, anti-HIV, and micellar properties of di- and trihydroxylated cationic surfactants. Tetrahedron 2002, 58, 1, 45.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	61880	1-hexadecene		C₁₆H₃₂	详情	详情
(II)	61879	1-bromo-2-hexadecanol		C₁₆H₃₃BrO	详情	详情
(III)	61881	2-bromo-1-hexadecanol		C₁₆H₃₃BrO	详情	详情
(IV)	44237	2-(dimethylamino)-1-ethanol	108-01-0	C₄H₁₁NO	详情	详情

Extended Information