benzyl (E)-4-bromo-2-butenyl ether; 1-({[(E)-4-bromo-2-butenyl]oxy}methyl)benzene -Drug Synthesis Database

【结构式】

【分子编号】61680

【品名】benzyl (E)-4-bromo-2-butenyl ether; 1-({[(E)-4-bromo-2-butenyl]oxy}methyl)benzene

【CA登记号】

【分子式】C₁₁H₁₃BrO

【分子量】241.12762

【元素组成】C 54.79% H 5.43% Br 33.14% O 6.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The intermediate phenylacetic acid allyl ester (IV) is prepared by two methods. Reaction of trans-1,4-dibromo-2-butene (I) with benzyl alcohol under phase-transfer conditions provides the benzyl ether (II). Subsequent DBU-mediated coupling of (II) with (4-methoxyphenyl)acetic acid (III) yields ester (IV).

参考文献中间体

合成目标

【1】 Kottirsch, G.; et al.; beta-Aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. J Med Chem 2002, 45, 11, 2289.
【2】 Kottirsch, G.; Neumann, U. (Novartis AG); Hydroxamic acid derivs.. EP 0929517; JP 2000508338; US 2002003804; US 6500983; WO 9814424 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18349	(E)-1,4-dibromo-2-butene；trans-1,4-dibromo-2-butene	821-06-7	C₄H₆Br₂	详情	详情
(II)	61680	benzyl (E)-4-bromo-2-butenyl ether; 1-({[(E)-4-bromo-2-butenyl]oxy}methyl)benzene		C₁₁H₁₃BrO	详情	详情
(III)	34794	(E)-3-chloro-2,3-bis(4-methoxyphenyl)-2-propenal		C₁₇H₁₅ClO₃	详情	详情
(IV)	61681	(E)-4-(benzyloxy)-2-butenyl 2-(4-methoxyphenyl)acetate		C₂₀H₂₂O₄	详情	详情

Extended Information