|
【结 构 式】 
|
【分子编号】61652 【品名】2-[(2-{2-[(1,4-dihydroxy-2-naphthyl)sulfanyl]ethoxy}ethyl)sulfanyl]-1,4-naphthalenediol 【CA登记号】 |
【 分 子 式 】C24H22O5S2 【 分 子 量 】454.56768 【元素组成】C 63.41% H 4.88% O 17.6% S 14.11% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of 1,4-naphthoquinone (I) with bis(2-mercaptoethyl) ether (II) produces the bis-(dihydroxynaphthalene) adduct (III), which is spontaneously oxidized to the bis-napthoquinone derivative (IV). Then, cyclization of (IV) with further bis-mercapto ether (II) in DMF under a positive pressure of O2 leads to the target crown ether derivative.
| 【1】 Huang, S.-T.; et al.; Efficient synthesis of "redox-switched" naphthoquinone thiol-crown ethers and their biological activity evaluation. Bioorg Med Chem 2002, 10, 6, 1947. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16561 | naphthoquinone; 1,4-Naphthoquinone | 130-15-4 | C10H6O2 | 详情 | 详情 |
| (II) | 61651 | Di-2-mercaptoethyl ether; 2-MERCAPTOETHYL ETHER; 2,2'-OXYDIETHANETHIOL; Di(2-mercaptoethyl) Ether; 2-Mercaptoethyl Ether; Bis(2-mercaptoethyl) ether; 2-Mercaptoethyl ether; 2,2'-Dithiodiethyl ether; (2,2'-OXYDIETHANETHIOL) | 2150-02-9 | C4H10OS2 | 详情 | 详情 |
| (III) | 61652 | 2-[(2-{2-[(1,4-dihydroxy-2-naphthyl)sulfanyl]ethoxy}ethyl)sulfanyl]-1,4-naphthalenediol | C24H22O5S2 | 详情 | 详情 | |
| (IV) | 61653 | 2-[(2-{2-[(1,4-dioxo-1,4-dihydro-2-naphthalenyl)sulfanyl]ethoxy}ethyl)sulfanyl]naphthoquinone | C24H18O5S2 | 详情 | 详情 |
Extended Information