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【结 构 式】

【分子编号】61651

【品名】Di-2-mercaptoethyl ether; 2-MERCAPTOETHYL ETHER; 2,2'-OXYDIETHANETHIOL; Di(2-mercaptoethyl) Ether; 2-Mercaptoethyl Ether; Bis(2-mercaptoethyl) ether; 2-Mercaptoethyl ether; 2,2'-Dithiodiethyl ether; (2,2'-OXYDIETHANETHIOL)

【CA登记号】2150-02-9

【 分 子 式 】C4H10OS2

【 分 子 量 】138.2548

【元素组成】C 34.75% H 7.29% O 11.57% S 46.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Condensation of 1,4-naphthoquinone (I) with bis(2-mercaptoethyl) ether (II) produces the bis-(dihydroxynaphthalene) adduct (III), which is spontaneously oxidized to the bis-napthoquinone derivative (IV). Then, cyclization of (IV) with further bis-mercapto ether (II) in DMF under a positive pressure of O2 leads to the target crown ether derivative.

1 Huang, S.-T.; et al.; Efficient synthesis of "redox-switched" naphthoquinone thiol-crown ethers and their biological activity evaluation. Bioorg Med Chem 2002, 10, 6, 1947.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 16561 naphthoquinone; 1,4-Naphthoquinone 130-15-4 C10H6O2 详情 详情
(II) 61651 Di-2-mercaptoethyl ether; 2-MERCAPTOETHYL ETHER; 2,2'-OXYDIETHANETHIOL; Di(2-mercaptoethyl) Ether; 2-Mercaptoethyl Ether; Bis(2-mercaptoethyl) ether; 2-Mercaptoethyl ether; 2,2'-Dithiodiethyl ether; (2,2'-OXYDIETHANETHIOL) 2150-02-9 C4H10OS2 详情 详情
(III) 61652 2-[(2-{2-[(1,4-dihydroxy-2-naphthyl)sulfanyl]ethoxy}ethyl)sulfanyl]-1,4-naphthalenediol C24H22O5S2 详情 详情
(IV) 61653 2-[(2-{2-[(1,4-dioxo-1,4-dihydro-2-naphthalenyl)sulfanyl]ethoxy}ethyl)sulfanyl]naphthoquinone C24H18O5S2 详情 详情
Extended Information