4-Aminoquinaldine; 4-Amino-2-methylquinoline; 4-Amino-2-Methylquinoline; 4-Aminoquinaldine; 4-Amino-2-methylchinolin -Drug Synthesis Database

【结构式】

【分子编号】61469

【品名】4-Aminoquinaldine; 4-Amino-2-methylquinoline; 4-Amino-2-Methylquinoline; 4-Aminoquinaldine; 4-Amino-2-methylchinolin

【CA登记号】6628-04-2

【分子式】C₁₀H₁₀N₂

【分子量】158.20288

【元素组成】C 75.92% H 6.37% N 17.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Acylation of aniline (I) with chloroacetyl chloride (II) in cold CH2Cl2 provides 2-chloro-N-phenylacetamide (III). Then, condensation of (III) with 4-aminoquinaldine (IV) in the presence of NaH in an inert atmosphere furnishes the title compound

参考文献中间体

合成目标

【1】 Sahu, N.P.; et al.; Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide- A potential antileishmanial agent. Bioorg. Med. Chem. 2002, 10, 6, 1687.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12294	Aniline; Phenylamine	62-53-3	C₆H₇N	详情	详情
(II)	11296	2-Chloroacetyl chloride; Chloroacetic chloride	79-04-9	C₂H₂Cl₂O	详情	详情
(III)	60932	2-chloro-N-phenylacetamide		C₈H₈ClNO	详情	详情
(IV)	61469	4-Aminoquinaldine; 4-Amino-2-methylquinoline; 4-Amino-2-Methylquinoline; 4-Aminoquinaldine; 4-Amino-2-methylchinolin	6628-04-2	C₁₀H₁₀N₂	详情	详情

Extended Information