-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide

【CA登记号】

【分子式】C₁₈H₁₇N₃O

【分子量】291.35569

【开发单位】Indian Institute of Chemical Biology (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antileishmanials, Treatment of Protozoal Diseases

合成路线1

Acylation of aniline (I) with chloroacetyl chloride (II) in cold CH2Cl2 provides 2-chloro-N-phenylacetamide (III). Then, condensation of (III) with 4-aminoquinaldine (IV) in the presence of NaH in an inert atmosphere furnishes the title compound

参考文献中间体

【1】 Sahu, N.P.; et al.; Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide- A potential antileishmanial agent. Bioorg. Med. Chem. 2002, 10, 6, 1687.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12294	Aniline; Phenylamine	62-53-3	C₆H₇N	详情	详情
(II)	11296	2-Chloroacetyl chloride; Chloroacetic chloride	79-04-9	C₂H₂Cl₂O	详情	详情
(III)	60932	2-chloro-N-phenylacetamide		C₈H₈ClNO	详情	详情
(IV)	61469	4-Aminoquinaldine; 4-Amino-2-methylquinoline; 4-Amino-2-Methylquinoline; 4-Aminoquinaldine; 4-Amino-2-methylchinolin	6628-04-2	C₁₀H₁₀N₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)