methyl 2-oxo-3-phenylpropanoate -Drug Synthesis Database

【结构式】

【分子编号】61468

【品名】methyl 2-oxo-3-phenylpropanoate

【CA登记号】

【分子式】C₁₀H₁₀O₃

【分子量】178.1876

【元素组成】C 67.41% H 5.66% O 26.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Methylation of phenylpyruvic acid (I) with iodomethane and DBU affords the methyl phenylpyruvate (II). Subsequent condensation of keto ester (II) with 2,3-dihydroxybenzaldehyde (III) in the presence of DBU, followed by acidic quenching provides the target furanone derivative

参考文献中间体

合成目标

【1】 Weber, V.; et al.; Novel 4,5-diaryl-3-hydroxy-2(5H)-furanones as anti-oxidants and anti-inflammatory agents. Bioorg. Med. Chem. 2002, 10, 6, 1647.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	55130	2-Oxophenylpropionic acid; Alpha-keto-DL-phenylalanine; Benzylglyoxylic acid; Phenylpyruvic acid	156-06-9	C₉H₈O₃	详情	详情
(II)	61468	methyl 2-oxo-3-phenylpropanoate		C₁₀H₁₀O₃	详情	详情
(III)	12380	2,3-Dihydroxybenzaldehyde	24677-78-9	C₇H₆O₃	详情	详情

Extended Information