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【结 构 式】 
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【药物名称】 【化学名称】5-(2,3-Dihydroxyphenyl)-3-hydroxy-4-phenylfuran-2(5H)-one 【CA登记号】 【 分 子 式 】C16H12O5 【 分 子 量 】284.27104 |
【开发单位】Univ. Blaise Pascal-Clermont-Ferrand II (Originator), Université d'Auvergne-Clermont-Ferrand (Originator) 【药理作用】Acute Myocardial Infarction, Treatment of, Antiarthritic Drugs, CARDIOVASCULAR DRUGS, Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Free Radical Scavengers, Lipid Peroxidation Inhibitors |
合成路线1
Methylation of phenylpyruvic acid (I) with iodomethane and DBU affords the methyl phenylpyruvate (II). Subsequent condensation of keto ester (II) with 2,3-dihydroxybenzaldehyde (III) in the presence of DBU, followed by acidic quenching provides the target furanone derivative
| 【1】 Weber, V.; et al.; Novel 4,5-diaryl-3-hydroxy-2(5H)-furanones as anti-oxidants and anti-inflammatory agents. Bioorg. Med. Chem. 2002, 10, 6, 1647. |