(2E,4E,6E,8E)-2,4,6,8-decatetraenedioic acid -Drug Synthesis Database

【结构式】

【分子编号】61445

【品名】(2E,4E,6E,8E)-2,4,6,8-decatetraenedioic acid

【CA登记号】

【分子式】C₁₀H₁₀O₄

【分子量】194.187

【元素组成】C 61.85% H 5.19% O 32.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The Horner-Wadsworth-Emmons condensation of (E,E)-muconaldehyde (I) with triethyl phosphonoacetate (II) by means of Ba(OH)2 in THF/water gives (E,E,E,E)-decatetraenedioic acid diethyl ester (III), which is hydrolyzed with LiOH to provide the target intermediate; the (E,E,E,E)-decatetraenedioic acid (IV).

参考文献中间体

合成目标

【1】 Vosburg, D.A.; et al.; Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470. Chirality 2003, 15, 2, 156.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	61443	E,E-2,4-Hexadienedial; E,Z-2,4-Hexadienedial; transtrans-Muconaldehyde		C₆H₆O₂	详情	详情
(II)	13272	Methyl 2-(dimethoxyphosphoryl)acetate; Trimethyl phosphoroacetate	5927-18-4	C₅H₁₁O₅P	详情	详情
(III)	61444	diethyl (2E,4E,6E,8E)-2,4,6,8-decatetraenedioate		C₁₄H₁₈O₄	详情	详情
(IV)	61445	(2E,4E,6E,8E)-2,4,6,8-decatetraenedioic acid		C₁₀H₁₀O₄	详情	详情

Extended Information