|
【结 构 式】 
|
【分子编号】61443 【品名】E,E-2,4-Hexadienedial; E,Z-2,4-Hexadienedial; transtrans-Muconaldehyde 【CA登记号】 |
【 分 子 式 】C6H6O2 【 分 子 量 】110.11244 【元素组成】C 65.45% H 5.49% O 29.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The Horner-Wadsworth-Emmons condensation of (E,E)-muconaldehyde (I) with triethyl phosphonoacetate (II) by means of Ba(OH)2 in THF/water gives (E,E,E,E)-decatetraenedioic acid diethyl ester (III), which is hydrolyzed with LiOH to provide the target intermediate; the (E,E,E,E)-decatetraenedioic acid (IV).
| 【1】 Vosburg, D.A.; et al.; Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470. Chirality 2003, 15, 2, 156. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 61443 | E,E-2,4-Hexadienedial; E,Z-2,4-Hexadienedial; transtrans-Muconaldehyde | C6H6O2 | 详情 | 详情 | |
| (II) | 13272 | Methyl 2-(dimethoxyphosphoryl)acetate; Trimethyl phosphoroacetate | 5927-18-4 | C5H11O5P | 详情 | 详情 |
| (III) | 61444 | diethyl (2E,4E,6E,8E)-2,4,6,8-decatetraenedioate | C14H18O4 | 详情 | 详情 | |
| (IV) | 61445 | (2E,4E,6E,8E)-2,4,6,8-decatetraenedioic acid | C10H10O4 | 详情 | 详情 |
Extended Information