(4aS,10aR)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】61422

【品名】(4aS,10aR)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylate

【CA登记号】

【分子式】C₁₆H₂₀NO₃

【分子量】274.33974

【元素组成】C 70.05% H 7.35% N 5.11% O 17.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The benzoquinoline carboxylate ester (I) is hydrolyzed with NaOH to produce the sodium carboxylate salt (II). Activation of (II) with propane-phosphonic anhydride, followed by coupling with N-(4-nitrophenyl)piperazine (III) furnishes the corresponding amide.

参考文献中间体

合成目标

【1】 Neumann, P.; Pfaeffli, P.; Seiler, M.P.; Swoboda, R. (Novartis AG; Novartis Deutschland GmbH); Benzo[g]quinoline derivs.. EP 0839136; JP 1999509197; US 5885988; WO 9703054 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	61421	methyl (4aS,10aR)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylate		C₁₇H₂₃NO₃	详情	详情
(II)	61422	(4aS,10aR)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylate		C₁₆H₂₀NO₃	详情	详情
(III)	20299	1-(4-nitrophenyl)piperazine	6269-89-2	C₁₀H₁₃N₃O₂	详情	详情

Extended Information