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【结 构 式】

【药物名称】SRA-880, NVP-SRA-880

【化学名称】1-[(3R,4aR,10aR)-6-Methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-3-yl)-1-[4-(4-nitrophenyl)piperazin-1-yl]methanone malonate

【CA登记号】

【 分 子 式 】C29H36N4O8

【 分 子 量 】568.63227

【开发单位】Novartis (Originator)

【药理作用】Antipsychotic Drugs, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, Somatostatin SRIF2A (sst1) Antagonists

合成路线1

The benzoquinoline carboxylate ester (I) is hydrolyzed with NaOH to produce the sodium carboxylate salt (II). Activation of (II) with propane-phosphonic anhydride, followed by coupling with N-(4-nitrophenyl)piperazine (III) furnishes the corresponding amide.

1 Neumann, P.; Pfaeffli, P.; Seiler, M.P.; Swoboda, R. (Novartis AG; Novartis Deutschland GmbH); Benzo[g]quinoline derivs.. EP 0839136; JP 1999509197; US 5885988; WO 9703054 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 61421 methyl (4aS,10aR)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylate C17H23NO3 详情 详情
(II) 61422 (4aS,10aR)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylate C16H20NO3 详情 详情
(III) 20299 1-(4-nitrophenyl)piperazine 6269-89-2 C10H13N3O2 详情 详情
Extended Information