【结 构 式】 |
【分子编号】61315 【品名】1-(4-bromophenyl)-1,3-butanedione 【CA登记号】 |
【 分 子 式 】C10H9BrO2 【 分 子 量 】241.08426 【元素组成】C 49.82% H 3.76% Br 33.14% O 13.27% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Claisen condensation of 4-bromoacetophenone (I) with ethyl acetate provides diketone (II). Subsequent reaction of (II) with carbon disulfide in the presence of LDA leads to thiopyranone thiol (III). Alkylation of thiol (III) with iodoethane and K2CO3 affords sulfide (IV), which is further oxidized to sulfoxide (V) by means of mCPBA. Displacement of either sulfide (IV) or sulfoxide (V) with morpholine gives rise to the morpholinyl thiopyranone (VI). Finally, Suzuki coupling between aryl bromide (VI) and 2-naphthaleneboronic acid (VII) produces the target compound
【1】 Griffin, R.J.; Combinatorial methods for identifying antitumour kinase inhibitors. Eur J Cancer 2002, 38, Suppl. 7. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25421 | 1-(4-bromophenyl)-1-ethanone | 99-90-1 | C8H7BrO | 详情 | 详情 |
(II) | 61315 | 1-(4-bromophenyl)-1,3-butanedione | C10H9BrO2 | 详情 | 详情 | |
(III) | 61316 | 2-(4-bromophenyl)-6-sulfanyl-4H-thiopyran-4-one | C11H7BrOS2 | 详情 | 详情 | |
(IV) | 61317 | 2-(4-bromophenyl)-6-(ethylsulfanyl)-4H-thiopyran-4-one | C13H11BrOS2 | 详情 | 详情 | |
(V) | 61318 | 2-(4-bromophenyl)-6-(ethylsulfinyl)-4H-thiopyran-4-one | C13H11BrO2S2 | 详情 | 详情 | |
(VI) | 61319 | 2-(4-bromophenyl)-6-(4-morpholinyl)-4H-thiopyran-4-one | C15H14BrNO2S | 详情 | 详情 | |
(VII) | 27703 | 1-naphthylboronic acid | 13922-41-3 | C10H9BO2 | 详情 | 详情 |
Extended Information