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【结 构 式】 
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【药物名称】NU-7279 【化学名称】2-(4-Morpholinyl)-6-[4-(1-naphthyl)phenyl]-4H-thiopyran-4-one 【CA登记号】500169-73-3 【 分 子 式 】C25H21NO2S 【 分 子 量 】399.51562 |
【开发单位】Cancer Research Technology (Originator), Kudos Pharmaceuticals (Originator) 【药理作用】Antineoplastic Enhancing Agents, Modulators of the Therapeutic Activity of Antineoplastic Agents, ONCOLYTIC DRUGS, Radiation Therapy, Radiosensitizers, DNA-Dependent Protein Kinase (DNA-PK) Inhibitors |
合成路线1
Claisen condensation of 4-bromoacetophenone (I) with ethyl acetate provides diketone (II). Subsequent reaction of (II) with carbon disulfide in the presence of LDA leads to thiopyranone thiol (III). Alkylation of thiol (III) with iodoethane and K2CO3 affords sulfide (IV), which is further oxidized to sulfoxide (V) by means of mCPBA. Displacement of either sulfide (IV) or sulfoxide (V) with morpholine gives rise to the morpholinyl thiopyranone (VI). Finally, Suzuki coupling between aryl bromide (VI) and 2-naphthaleneboronic acid (VII) produces the target compound
| 【1】 Griffin, R.J.; Combinatorial methods for identifying antitumour kinase inhibitors. Eur J Cancer 2002, 38, Suppl. 7. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25421 | 1-(4-bromophenyl)-1-ethanone | 99-90-1 | C8H7BrO | 详情 | 详情 |
| (II) | 61315 | 1-(4-bromophenyl)-1,3-butanedione | C10H9BrO2 | 详情 | 详情 | |
| (III) | 61316 | 2-(4-bromophenyl)-6-sulfanyl-4H-thiopyran-4-one | C11H7BrOS2 | 详情 | 详情 | |
| (IV) | 61317 | 2-(4-bromophenyl)-6-(ethylsulfanyl)-4H-thiopyran-4-one | C13H11BrOS2 | 详情 | 详情 | |
| (V) | 61318 | 2-(4-bromophenyl)-6-(ethylsulfinyl)-4H-thiopyran-4-one | C13H11BrO2S2 | 详情 | 详情 | |
| (VI) | 61319 | 2-(4-bromophenyl)-6-(4-morpholinyl)-4H-thiopyran-4-one | C15H14BrNO2S | 详情 | 详情 | |
| (VII) | 27703 | 1-naphthylboronic acid | 13922-41-3 | C10H9BO2 | 详情 | 详情 |