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【结 构 式】

【分子编号】61278

【品名】(11aS)-7,8-dimethoxy-2-(4-methoxyphenyl)-10-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

【CA登记号】

【 分 子 式 】C27H34N2O6Si

【 分 子 量 】510.66234

【元素组成】C 63.51% H 6.71% N 5.49% O 18.8% Si 5.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XII)

Treatment of ketone (IX) with trifluoromethanesulfonic anhydride and pyridine produces the vinyl triflate (X). This is then subjected to Suzuki coupling with 4-methoxyphenylboronic acid (XI) to yield adduct (XII). Finally, regioselective lactam reduction in (XII) with NaBH4 furnishes the title compound.

1 Thurston, D.E.; Howard, P.W. (University of Portsmouth); Compounds. EP 1109812; WO 0012508 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 61276 (11aS)-7,8-dimethoxy-10-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,1-c][1,4]benzodiazepine-2,5,11(3H,10H,11aH)-trione C20H28N2O6Si 详情 详情
(X) 61277 (11aS)-7,8-dimethoxy-5,11-dioxo-10-{[2-(trimethylsilyl)ethoxy]methyl}-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl trifluoromethanesulfonate C21H27F3N2O8SSi 详情 详情
(XI) 39246 4-methoxyphenylboronic acid 5720-07-0 C7H9BO3 详情 详情
(XII) 61278 (11aS)-7,8-dimethoxy-2-(4-methoxyphenyl)-10-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione C27H34N2O6Si 详情 详情
Extended Information